Available Positions

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PhD position in heart reneration at the Weidinger Lab in Ulm University

Deadline: April 30th 2021; Location: Ulm University (Germany)

While heart injury results in permanent damage in adult mammals including humans, zebrafish can efficiently regenerate the heart. Our lab studies the underlying cellular and molecular mechanisms (Bertozzi et al Dev. Biol 2021, Honkoop et al elife 2019, Wu et al Dev. Cell 2016, Zebrowski et al., elife 2015, Schnabel et al., PLOS One 2011). Cardiomyocytes are regenerated from spared differentiated cardiomyocytes, which dedifferentiate and re-enter the cell cycle. Surprisingly, we have found that proliferating cardiomyocytes experience replication stress, which is a major reason for declining regenerative abilities in aged mammals. Zebrafish can overcome the replication stress with the help of BMP signaling. Thus, we speculate that zebrafish heart regeneration depends on an elevated ability to overcome roadblocks that cause declining tissue renewal during aging in mammals, suggesting that zebrafish regeneration can be used to identify anti-aging mechanisms. The successful PhD candidate will use state-of-the art in vivo experiments in zebrafish, including Cre-lox based transgenics, genetic mutants and RNASeq to test this hypothesis and to identify mechanisms by which BMP signaling alleviates replication stress. The project is embedded in a collaborate research initiative (SFB) of Ulm University

We are looking for an enthusiastic, highly motivated scientist (f/m/d) who is dedicated to performing fundamental research.

We expect:

  •     Training in developmental biology, molecular biology, cellular biology or related fields.
  •     Enthusiasm for regenerative biology.
  •     Excellent communication skills in spoken and written English.

We offer:

  •     The opportunity to work in an international, dynamic and motivated team.
  •     State-of-the art resources, including a 1000 tank zebrafish facility.
  •     The possibility to join the international graduate school of Ulm University, iGradU.
  •     Payment and benefits according to the collective agreement TV-L 13.

Applications including a CV, a statement of research experience and interests (max. 2 pages), and contact data for 2-3 references should be emailed to Prof. Dr. Gilbert Weidinger, gilbert.weidinger@uni-ulm.de

Laboratory Technician Position at Luxembourg Centre for Systems Biomedicine

Deadline: May? 2021; Location: Luxembourg Centre for Systems Biomedicine (Luxembourg)

We seek a highly skilled and motivated laboratory technician to work on an EU-funded research project within an international consortium that focuses on two inherited disorders of lysine metabolism causing debilitating and progressive neurological symptoms in young children. In brief, the Luxembourg contribution to the project includes the generation and deep characterization of several in vivo disease models using zebrafish to ultimately evaluate a number of innovative strategies to improve early diagnosis and early implementation of personalized therapies to enhance long-term health outcomes and patients’ quality of life.

To know more about it:

http://emea3.mrted.ly/2nvdn

Researcher Position at Luxembourg Centre for Systems Biomedicine

Deadline: May? 2021; Location: Luxembourg Centre for Systems Biomedicine (Luxembourg)

Research & Development Specialist in Systems Biomedicine with focus on disease modeling: We seek a highly skilled and motivated researcher to develop an EU-funded project within an international consortium that focuses on two rare disorders of lysine metabolism causing debilitating and progressive neurological symptoms in young children. In brief, the Luxembourg contribution to the project includes the generation and deep characterization of several in vivo disease models using zebrafish to ultimately evaluate a number of innovative strategies to improve early diagnosis and early implementation of personalized therapies to enhance long-term health outcomes and patients’ quality of life.

To know more about it:

http://emea3.mrted.ly/2nvki

Two tenure track Assistant Professor positions in Developmental Biology

Deadline: 7 March 2021; Location: Utrecht University (Netherlands)

At the division of Developmental Biology in the Department of Biology of Utrecht University, we are seeking two enthusiastic and ambitious scientists to strengthen our research and teaching activities. You will be given the opportunity to set up your own line of research and will participate in teaching at the Bachelor’s and Master’s level.

To know more about it:

Click here for Utrecht University web page and here to download a PDF on the position